• Biomarker changes as surrogate endpoints in early-phase trials in heart failure with reduced ejection fraction 

      Savarese, Gianluigi; Uijl, Alicia; Ouwerkerk, Wouter; Tromp, Jasper; Anker, Stefan D.; Dickstein, Kenneth; Hage, Camilla; Lam, Carolyn S.P.; Lang, Chim C.; Metra, Marco; Ng, Leong L.; Orsini, Nicola; Samani, Nilesh J.; van Veldhuisen, Dirk J.; Cleland, John G.F.; Voors, Adriaan A.; Lund, Lars H. (Journal article; Peer reviewed, 2022)
      Aims No biomarker has achieved widespread acceptance as a surrogate endpoint for early-phase heart failure (HF) trials. We assessed whether changes over time in a panel of plasma biomarkers were associated with subsequent ...
    • Repetitive use of levosimendan for treatment of chronic advanced heart failure: Clinical evidence, practical considerations, and perspectives: An expert panel consensus 

      Nieminen, Markku Sakari; Altenberger, Johann; Ben-Gal, Tuvia; Böhmer, Armin; Comin-Colet, Josep; Dickstein, Kenneth; Édes, István Ferenc; Fedele, Francesco; Fonseca, Cândida; García-González, Martín J.; Giannakoulas, Georgios A.; Iakobishvili, Zaza; Jääskeläinen, Pertti; Karavidas, Apostolos I.; Kettner, Jiří; Kivikko, Matti; Lund, Lars H.; Matskeplishvili, Simon T.; Metra, Marco; Morandi, Fabrizio; Oliva, Fabrízio A.; Parkhomenko, Alexander; Parissis, John T.; Pollesello, Piero; Pölzl, Gerhard; Schwinger, Robert H.G.; Segovia, Javier; Seidel, Monika; Vrtovec, Bojan; Wikström, Gerhard (Peer reviewed; Journal article, 2014-06-15)
      Background The intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In the last decade scientific and clinical interest has arisen for its repetitive or ...
    • What determines who gets cardiac resynchronization therapy in Europe? A comparison between ESC-HF-LT registry, SwedeHF registry, and ESC-CRT Survey II 

      Gatti, Paolo; Linde, Cecilia; Benson, Lina; Thorvaldsen, Tonje; Normand, Camilla Jacqueline Hansine; Savarese, Gianluigi; Dahlström, Ulf; Maggioni, Aldo P.; dickstein, kenneth; Lund, Lars H. (Journal article; Peer reviewed, 2023)
      Aims Cardiac resynchronization therapy (CRT) is effective in heart failure with reduced ejection fraction (HFrEF) and dyssynchrony but is underutilized. In a cohort study, we identified clinical, organizational, and ...